Michael C. Pirrung, Ph.D.
Department of Chemistry, UC Riverside
PUBLICATIONS
These are some of the most recent publications. In total, there are over 160 publications.
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Michael C. Pirrung, Fa Zhang, Sudhakar Ambadi, and Y. Gangadhara Rao, “Total Synthesis of the Fellutamides, Lipopeptide Proteasome Inhibitors. More Sustainable Peptide Bond Formation,” J. Org. Chem., 80, 000 (2015). Click here to view.
Michael C. Pirrung, Goutam Biswas, Natalie De Howitt, and Jiayu Liao, “Synthesis and Bioluminescence of Difluoroluciferin,” Bioorg. Med. Chem. Lett., 24, 4881 (2014). Click here to view.
Michael C. Pirrung and Edwin M. Southern, “The Genesis of Microarrays,” Biochem. Mol. Biol. Ed., 42, 106 (2014). Click here to view.
Simmy Thomas, Natasha Sharma, Reyna Gonzalez, Peng-Wen Pao, Florence M. Hofman, Thomas C. Chen, Stan G. Louie, Michael C. Pirrung, and Axel H. Schönthal, “Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I,” PLOS One, 8, e65695 (2013). Click here to view.
Michael C. Pirrung and Jenifer N. Nalbandian, “Catalyzed Claisen Rearrangements of O-Allyl Kojates,” Tetrahedron Lett., 54, 3752 (2013). Click here to view.
John Opoku-Ansah, Tannya R. Ibarra-Rivera, Michael C. Pirrung, and André S. Bachmann, “Syringolin B-inspired Proteasome Inhibitor Analogue TIR-203 Exhibits Enhanced Biological Activity in Multiple Myeloma and Neuroblastoma,” Pharm. Biol., 50, 25 (2012).
Yongfeng Zhao, Michael C. Pirrung, and Jiayu Liao, “A Fluorescent Amino Acid Probe to Monitor Efficiency of Peptide Conjugation to Glass Surfaces for High Density Microarrays,” Mol. Biosyst., 8, 879 (2012). Click here to view.
Michael C. Pirrung, Fa Zhang, Sudhakar Ambadi, and Tannya R. Ibarra-Rivera, “Reactive Esters in Amide Ligation with b-Hydroxyamines,” Eur. J. Org. Chem., 4283 (2012). Click here to view.
Tannya R. Ibarra-Rivera, John Opoku-Ansah, Sudhakar Ambadi, André S. Bachmann, and Michael C. Pirrung, “Synthesis and Cytotoxicity of Syringolin B-Based Proteasome Inhibitors,” Tetrahedron, 67, 9950 (2011). Click here to view.
Ashish Anshu, Simmy Thomas, Puneet Agarwal, Tannya R. Ibarra-Rivera, Michael C. Pirrung, Axel H. Schönthal, “Novel Proteasome-Inhibitory Syrbactin Analogs That Trigger Endoplasmic Reticulum Stress and Induce Apoptosis in Hematological Tumor Cell Lines,” Biochem. Pharmacol. 82, 600 (2011). Click here to view.
Michael C. Pirrung, Timothy M. Dore, Vipul S. Rana, and Yue Zhu, “Sensitized Two-photon Photochemical Deprotection,” Chem. Commun., 5313 (2010). Click here to view.
Michael C. Pirrung, Goutam Biswas, and Tannya R. Ibarra-Rivera, “Total Synthesis of Syringolin A and B,” Org. Lett., 12, 2402 (2010).
Michael C. Pirrung, Biswajit G. Roy, and Surendra Gadamsetty, “Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone Photoremovable Protecting Groups,” Tetrahedron, 66, 3147 (2010). Click here to view.
Marci Surpin, Yunfan Zou, Chiyi Xiong, Natasha V. Raikhel, and Michael C. Pirrung, “Iodine Scanning of a Phenazine Inhibitor of Vacuolar Sorting,” Bioorg. Med. Chem. Lett., 20, 1496 (2010). Click here to view.
Michael C. Pirrung and Jianmei Wang, ”Multicomponent Reactions of Cyclobutanones,” J. Org. Chem., 74, 2958 (2009). Click here to view.
Michael C. Pirrung, Subir Ghorai, and Tannya R. Ibarra-Rivera, “Multicomponent Reactions of Convertible Isonitriles,” J. Org. Chem., 74, 4110 (2009). Click here to view.
Nicholas J. G. Webster and Michael C. Pirrung, “Small Molecule Activators of the Trk Receptors for Neuroprotection,” BMC Neurosci., 9 (Suppl. 2), S1 (2008). Click here to view.
Michael C. Pirrung, Koushik Das Sarma and Jianmei Wang, “Hydrophobicity and Mixing Effects on Select Heterogeneous, Water-Accelerated Synthetic Reactions,” J. Org. Chem., 73, 8723 (2008). Click here to view.
Michael C. Pirrung, Anthony B. Bleecker, Yoshihisa Inoue, Fernando Rodríguez, Norimitsu Sugawara, Takehiko Wada, Yunfan Zou, and Brad M. Binder, ”Ethylene Receptor Antagonists: Strained Alkenes Are Necessary But Not Sufficient,” Chem. Biol., 15, 313 (2008).
Yunfan Zou, Marcela Rojas-Pierce, Natasha V. Raikhel, and Michael C. Pirrung, ”Preparation of Methyl Ester Precursors of Biologically Active Agents,” BioTechniques, 44, 377 (2008). Click here to view.
Xin Xiong and Michael C. Pirrung, ”Modular Synthesis of Candidate Indole-based Insulin Mimics by Claisen Rearrangement,” Org. Lett., 10, 1151 (2008). Click here to view.
Michael C. Pirrung, Liu Deng, Bo Lin, and Nicholas J. G. Webster, ”Quinone Replacements for Small Molecule Insulin Mimics,” Chembiochem, 9, 360 (2008). Click here to view.
Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster, “Identification of Novel Orally-available Small Molecule Insulin Mimics,” J. Pharmacol. Exp. Ther., 323, 579 (2007). Click here to view.
Xin Xiong and Michael C. Pirrung, ”Practical Synthesis of 7-Prenylindole,” J. Org. Chem., 72, 5832 (2007). Click here to view.
Hyunsoo Kim, Liu Deng, Xin Xiong, William Hunter, Melissa Long, and Michael C. Pirrung, “Glyceraldehyde-3-phosphate Dehydrogenase is a Cellular Target of Demethylasterriquinone B1”, J. Med. Chem., 50, 3423 (2007). Click here to view.
Michael C. Pirrung, Zhitao Li, Yufa Liu, Erika Hensley, Aparna Tanksale, Bo Lin, Ashok Pai, and Nicholas J. G. Webster, ”Parallel Synthesis of Indolylquinones and Their Cell-based Insulin Mimicry,” J. Comb. Chem., 9, 844 (2007). Click here to view.
Bo Lin, Michael C. Pirrung, Liu Deng, Zhitao Li, Yufa Liu, and Nicholas J. G. Webster, “Neuroprotection by Small Molecule Activators of the NGF Receptor,” J. Pharmacol. Exp. Ther., 322, 59 (2007). Click here to view.
Michael C. Pirrung and Subir Ghorai, “Versatile, Fragrant, Convertible Isonitriles,” J. Am. Chem. Soc., 128, 11772 (2006).
Khisimuzi E. Mdluli, Pamela R. Witte, Toni Kline, Adam W. Barb, Alice L. Erwin, Bryce E. Mansfield, Amanda L. McClerren, Michael C. Pirrung, L. Nathan Tumey, Paul Warrener, Christian R. H. Raetz, and C. Kendall Stover, ”Molecular validation of LpxC as an antibacterial drug target in Pseudomonas aeruginosa,”Antimicrob. Agents Chemother. 50, 2178 (2006). Click here to view.
Michael C. Pirrung and Koushik Das Sarma, “Aqueous Medium Effects on Multi-component Reactions,” Tetrahedron, 61, 11456 (2005).
Michael C. Pirrung, Sunil V. Pansare, Koushik Das Sarma, Kathy A. Keith, and Earl R. Kern, “Combinatorial Optimization of Isatin-beta-Thiosemicarbazones as Anti-Poxvirus Agents,” J. Med. Chem., 48, 3045 (2005). Click here to view.
Michael C. Pirrung, Yufa Liu, Liu Deng, Diana K. Halstead, Zhitao Li, John F. May, Michael Wedel, Darrell A. Austin, and Nicholas J. G. Webster, ”Methyl Scanning: Total Syntheses of Demethylasterriquinone B1 and Derivatives for Identification of Sites of Interaction with and Isolation of Its Receptors,” J. Am. Chem. Soc., 127, 4609 (2005). Click here to view.
The ENCODE Project Consortium, “The ENCODE (ENCyclopedia of DNA Elements) Project,” Science, 306, 636-640 (2004).
